Papers
In the Spotlight
Aβ profiles generated by Alzheimer’s disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset
Petit, Gutiérrez-Fernández et al. (Molecular Psychiatry, 2022)
Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions
Szaruga et al. (Cell, 2017)
Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators
Petit et al. (EMBO J, 2019)